You have a few options here, you could just use a Sandbox to control the program you're executing, will still have safe from viruses and such.
Sandboxie which I recommend. http://www.sandboxie.com/
You could also use a Virtual Machine (VM) if you want, any virus you run on that VM won't be able to escape/leak to your main hard drive so you will stay safe.
Note: Using only an anti-virus won't and will never keep you safe 100%. So don't blindly run any program thinking that your AV is the heaven-dropped tool that will keep you safe from any threat on the internet.