By losing everything, do you mean applications etc?
If so, no, they're stored on the Hard Drive.
And by liquid cooled, do you mean a cpu cooling system like a h100? or a custom loop?
A System like a H100 can be easily transfer, a custom loop is also possible but is a lil harder as it will need to be drained of all fluid, then have the loop fitted to a brand new case which could be a problem with the lengths of loops.
Also, the build seems ok, my only question would be on the motherboard upgrade, i'm not familiar with either board so what is your reason for the upgrade?