This is simple. Hi, LifeAway here.
As for the "Get All Drops" it usually bugs out when grabbing items because it literally tries over and over until it responds to the accept spoof and if it fails too many times or grabs too many items, it can force a disconnection, making it dangerous to use without watching it.
The "Reject All Drops" and the whitelist usually never causes any issues such as removing the item you need to grab or disconnecting. It attempts to remove the chance to grab the item by spoofing a decline selection, therefore you're ignoring the item to make room for important items such as things in your whitelist. Important thing is, if it's not properly named, for example, Unidentified 13 as unidentified 13, will cause it to spoof a decline as it's not properly named, goes for all caps items as well, it has to be exactly like it [ignoring the x1 counter] or else it'll be gone. So what you're looking for if you think you lost your runes, have the whitelist as "Runes Found!" and "Legendary Runes" to correctly complete the quest AND get your "well-earned" runes.
Hope this helps!