League of Legends is nearly impossible to hack since most of the info is stored on their server, but it should be possible to make a skin hack, so you can see them before they gank you etc, or just remove the FoW, another small advantage would be seeing people in bushes.
If anyone has any info on this please reply.
PS:This game is free, so don't be scared to test hacks on it, since it takes the same time to get to their website as creating an account.