Ashiya has spent the first seven days of high school stuck in the infirmary because of a youkai attaching itself to him. He ends up asking the owner of a small tea room called the "Mononokean" for help. This is a tale involving the very morose owner of Mononokean guiding the youkai that happened to wander into this world go to the next world.
Ep 1: It's fairly similar to Mushishi except it's much more lighthearted and it's more of a slice of life, soft and relaxing anime with a comedic side. So far it definitely looks more interesting than Kyoukai no Rinne, but we'll see how that goes.