well if you mean mindfuck because of plot-twists: Shutter Island
mindfuck because of disgusting shit: The Human Centipede 1&2
mindfuck because of weird horror: V/H/S and maybe V/H/S 2, but the third one just sucks.
mindfuck because of mindfuck: Cloud Atlas, I stopped watching it after 2 hourse because I head major headache