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Good question.
As with many things this will definitely depend on the level of work and commitment you would like.
As an investor just wanting to put money I would look into #defi initiatives around Ethereum. A simple example would be
the compound protocol. You deposit and it starts "compounding". You can see the returns on that page.
As a proper entrepreneur willing to build the question is more complicated, I am not completely sure. I think those who can bridge normal people into this complicated space will profit big on the next coming years. Not only offering fiat>crypto options.
For example there are good initiatives on the issuing and validation of e-learning certificates. E-learning is a major topic nowadays but is still centralized on the
validation/issuing of the certications. There are forging problems with the certificates since they are mostly a pdf. When the institution validates publicly on a public blockchain there is no way to forge it.
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I have just posted above an example not related to "money" with a clear utilization of the technology. Forget your ideas about speculation, cryptocurrencies is the first implementation of blockchain. Not the only one.
Think about blockchain as the improvement of peer to peer technologies, no central validator. If you can't imagine how that will modify existing technology then of course you will still be seating on the "buzzword" table.