actually i moved to vista last night...just becuase it would be useful to help troubleshoot all the people with problems..
and from what i can tell, if you disable UAC you wont have any issues, thats all i have done and i still can run all my opk, harolds chams, and anything else i have tried so far
for those of you with vista that dont know what or how to disable UAC...
Disable User Account Control (UAC) the Easy Way on Windows Vista :: the How-To Geek
*note* harolds bypass is the only one i have tested since i switched to vista. when i get home from work i can start downloading everything else and try it out