This is quoted from L.Spiro himself, from his forums.

Memory Hacking Software :: View topic - Unable to open process

Roll back to Windows® Vista®. Kernel read/write of memory does not work on Windows® Vista® SP1.


L. Spiro
HackShield is only a factor because the kernel ReadProcessMemory() and WriteProcessMemory() function do not yet work on Windows® Vista® SP1.

Without the kernel routines, HackShield can detect and block the regular functions MHS uses Hence anything you do that required reading of RAM will not work, especially searches.


L. Spiro


Bottomline: MHS is not compatible with Windows Vista SP1. Either Rollback to Windows Vista, install Windows xp using VmWare, create a UCE(Undetected Cheat engine), or Stfu and wait.