Originally Posted by
Sydney-Life2009
This may stem from genetics. If you find that your calves are always sore without doing any hypertrophy work, it may be because you have a short achilles tendon. This tends to cause tightness in your soleus and gastrocnemius and leads to your calves overcompensating due to the shortness of the tendon. I recommend doing remedial stretches to stretch out your calves before doing strenuous activity.
Taking specific supplements isn't going to suddenly help one part of your body that is always sore. Just stick to eating well and taking protein if you find that you're lacking.