If you have the Win7/Vista version than yes. In windowed mode just set it to the resolution it was, and drag it as close as you can to the center of the screen. In game you wont notice your task bar, (unless its big, or bright) and you wont be missing much in terms of whats off the screen.
The XP one can run in full screen.
Also, make sure to run the python version, as the EXE has been detected.