Gamebooster works by shutting off non-essential processes, which you shouldn't be running in the first place, check your startup folder and msconfig to make sure there aren't useless things starting at boot. Don't use AVG or Avast, because both are slow at data sequencing and will slow down your computer, use Norton 360. As for defragging, Tuneup Utilities is good for that, as well as many other things including everything CCleaner can do. Turning off DEP will also increase gaming performance a bit. Lastly, change your page file sizes to 3072 minimum and 5120 maximum, too small a page file can cause a plethora of problems and too big of a page file can lead to significant fragmenting as well as more system heat and overall slower hdrive read write speeds.
But to answer your original question, no, not at all xD have fun =)