In PonyHack, you just need to shoot and the aimbot activates (or if it's in rage mode it's automatical ofc)
Nine-Elevenbot? You have to bind a command to some key. The command is +nine_eleven_aim or something.
In NanoHack, have you enabled the aimbot from F1 menu? Other than that, the aimbot should be automatical or it can be put to either LMB, RMB or MMB.